P0300 on Cadillac
Random/Multiple Cylinder Misfire Detected
P0300 on Cadillac vehicles indicates random/multiple cylinder misfire detected. Au7o has documented this code across 1 Cadillac model — most commonly on Escalade. P0300 means the engine computer detected misfires occurring randomly or across multiple cylinders rather than in one specific cylinder. A misfire is when a cylinder fails to ignite its fuel-air mixture properly, which the computer senses through small fluctuations in crankshaft speed. Because it's not isolated to one cylinder, the cause is usually something that affects the whole engine — like fuel, air, or ignition system problems — rather than a single coil or plug. Persistent or heavy misfiring wastes fuel, runs rough, and can damage the catalytic converter, which is why a flashing check engine light should be taken seriously.
Common Causes of P0300
- •Worn or fouled spark plugs (across cylinders)
- •Vacuum or intake air leak
- •Weak fuel pump, clogged fuel filter, or low fuel pressure
- •Failing ignition coils or worn spark plug wires
- •Dirty or faulty mass airflow (MAF) sensor
- •Clogged or dirty fuel injectors
- •Faulty crankshaft/camshaft position sensor
- •Low compression or EGR/PCV system faults
P0300 on Cadillac by Model
Cadillac Escalade(1 issue)
- Confirmed AFM Lifter Collapse Requires Generation-Specific Diagnosis2010-2020
GM separates the 2010-2014 L94 Gen IV and 2015-2020 L86 Gen V AFM diagnostic and repair paths. A P0300 misfire and loss of valve motion on AFM cylinders 1, 4, 6 or 7 require compression, VLOM and valvetrain checks; early 2007 L92 hardware had AFM disabled and is outside this corrected scope.
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View P0300 across all makes →Frequently Asked Questions
What does P0300 mean on Cadillac?▼
P0300 stands for "Random/Multiple Cylinder Misfire Detected." P0300 means the engine computer detected misfires occurring randomly or across multiple cylinders rather than in one specific cylinder. A misfire is when a cylinder fails to ignite its fuel-air mixture properly, which the computer senses through small fluctuations in crankshaft speed. Because it's not isolated to one cylinder, the cause is usually something that affects the whole engine — like fuel, air, or ignition system problems — rather than a single coil or plug. Persistent or heavy misfiring wastes fuel, runs rough, and can damage the catalytic converter, which is why a flashing check engine light should be taken seriously. On Cadillac specifically, this code is documented across 1 model.
What causes P0300 on Cadillac vehicles?▼
Common causes on Cadillac: Worn or fouled spark plugs (across cylinders), Vacuum or intake air leak, Weak fuel pump, clogged fuel filter, or low fuel pressure, Failing ignition coils or worn spark plug wires, Dirty or faulty mass airflow (MAF) sensor. Specific causes vary by model and year — see the per-model sections below.
How much does it cost to fix P0300 on a Cadillac?▼
Repair costs vary widely depending on the root cause and specific Cadillac model.
Which Cadillac models have P0300 documented?▼
Au7o has documented P0300 on 1 Cadillac model: Escalade.