According to Au7o's research across NHTSA recalls, manufacturer TSBs, and owner forum reports, the 1999 Ford F-250 Super Duty has 5 documented known issues, with 3 rated critical. The most serious are 6.8L V10 and 5.4L Triton 2-Valve Spark Plug Ejection from Aluminum Cylinder Head ($300-$1,500 repair), 7.3L Power Stroke Camshaft Position Sensor Failure - Sudden Stall and No Restart ($80-$300 repair) and Speed Control Deactivation Switch Underhood Fire - Recall 07V-078 ($0-$0 repair). Across all issues with published estimates, repair costs range from $80 to $1,500. DIY maintenance guides at au7o.io.